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British scientists make major Alzheimer’s breakthrough

first_img Share 28 Views   no discussions Tweet HealthLifestyle British scientists make major Alzheimer’s breakthrough by: – October 16, 2013 LONDON, England, Wednesday October 16, 2013 – A new British study has been lauded as a turning point in the search for a drug that could stop Alzheimer’s disease, following the pioneering use of a drug-like compound to halt brain cell death in mice.Published in the journal Science Translational Medicine, the study was conducted at the Medical Research Council’s (MRC) Toxicology Unit at the University of Leicester and is thought to provide a major new pathway for future drug treatments.The drug-like compound blocks a faulty signal in brains affected by neurodegenerative diseases that shuts down the production of essential protective proteins, resulting in the gradual death of brain cells.Researchers tested the compound in mice with prion disease – the closest animal model of human neurodegenerative disorders – but said they were confident the same principles would apply in a human brain with diseases like Alzheimer’s or Parkinson’s.In brain diseases such as Alzheimer’s, the production of new proteins in the brain is halted by an accumulation of amyloids or “misfolded proteins.” This leads to an over-activation of a natural defence mechanism that stops essential proteins being produced. In the absence of these protective proteins, brain cells die, resulting in diseases like Alzheimer’s.In the study, the compound inhibited an enzyme, known as PERK, which plays a key role in activating this defence mechanism. In mice with prion’s disease, it restored proteins to protect brain cells, restoring some normal behaviours, arresting memory loss and “stopping the disease in its tracks.”“It’s a real step forward,” team leader Professor Giovanna Mallucci told Britain’s Independent newspaper. “It’s the first time a substance has been given to mice that prevents brain disease. The fact that this is a compound that can be given orally, that gets into the brain and prevents brain disease, is a first in itself… We can go forward and develop better molecules and I can’t see why preventing this process should only be restricted to mice. I think this probably will translate into other mammalian brains.”While the compound produced side effects in mice, including weight loss and mild diabetes, Mallucci said it would “not be impossible” to develop a drug that protected the brain without the side effects and that work towards doing so had been promising.The landmark study received an enthusiastic reception from scientists, who nonetheless cautioned that it remained a significant proof of principle and a possible basis for new treatments, rather than a guarantee of an Alzheimer’s cure in the near future. BBC Newscenter_img Share Sharing is caring! Sharelast_img read more

Real Madrid: Benzema blasts Chelsea’s Oliver Giroud

first_img Loading… Now at Chelsea, Giroud has netted 39 goals in 93 appearances for France and is now behind only Thierry Henry and Michel Platini in the nation’s scoring charts, while he helped them to land the World Cup two summers ago. “You cannot confuse Formula 1 with karting, and I am being nice,” Benzema said on Instagram Live, as cited by El Mundo Deportivo, before adding, “I know that I am Formula 1. “It works because he is there, that is the only reason. It won’t be spectacular, he won’t do something amazing, but he has his thing. “Aside from that, does everyone like the way he plays? I don’t know.” Real Madrid striker Karim Benzema has taken aim at Chelsea forward Olivier Giroud by stating: ‘You cannot confuse Formula 1 with karting.’ Giroud has replaced Benzema in the France international team in the past four years with the Madrid striker not appearing for his nation since prior to the 2016 European Championships. Read Also: Lautaro Martinez would only leave Inter for BarcelonaBenzema has continued to thrive for Madrid in recent years, netting 30 goals last season – his best tally since 2011/12 – while he has already been involved in 20 goals in La Liga this campaign, scoring 14 times and providing six goals.Whilst Benzema has taken over the attacking mantle from Cristiano Ronaldo at Madrid, Giroud has become a fringe figure at Stamford Bridge.FacebookTwitterWhatsAppEmail分享 center_img Benzema has 27 goals from 81 international caps but has not appeared for Les Bleus in either of the last two major tournaments, with Giroud now the leading striker for the nation.Advertisement Promoted Content7 Facts About Black Holes That Will Blow Your Mind7 Ways To Understand Your Girlfriend Better10 Risky Jobs Some Women DoBest & Worst Celebrity Endorsed Games Ever MadeWhich Country Is The Most Romantic In The World?7 Things That Actually Ruin Your Phone8 Addictive And Fun Coffee Facts18 Cities With Neverending Tourist-FlowWho’s The Best Car Manufacturer Of All Time?5 Of The World’s Most Unique Theme Parks7 Universities In The World Where Education Costs Too MuchA Soviet Shot Put Thrower’s Record Hasn’t Been Beaten To This Daylast_img read more

Cup dates set for Wilkinson and co

first_img Wilkinson, the European Player of the Year, played a key role in the French club landing northern hemisphere club rugby’s biggest prize with victory over Clermont Auvergne in last season’s Dublin final. The 34-year-old former England international, who recently underwent a groin operation, will be hoping to launch another successful campaign with the Pool 2 meeting against the Warriors at Stade Felix Mayol on Sunday, October 13. Jonny Wilkinson’s Toulon will begin the defence of their Heineken Cup crown at home to Glasgow Warriors in October. Clermont, meanwhile, will face a testing examination in their Pool 4 opener as they travel to face Top 14 rivals Racing Metro on the same day. Saracens, beaten semi-finalists last term, travel to Connacht in Pool 3 on Friday, October 11, and will take another fixture to Wembley a week later for their mouthwatering meeting with French giants Toulouse. Ulster and Leicester will meet in a crunch Pool 5 engagement on the opening night of the tournament at Ravenhill, and another eagerly-anticipated clash will see Amlin Challenge Cup holders Leinster travel to face the Ospreys in Pool 1 on Saturday, October 12. The other fixture in Pool 1 on the first weekend sees Northampton travel to Castres, while the Saints’ away trip to Leinster in December, a repeat of the memorable 2011 final, will be played at the Aviva Stadium. In Toulon’s group, Cardiff Blues travel to Exeter before hosting the French side the following weekend in what will be the first European club game played on an artificial pitch at the Arms Park. Harlequins kick off their Pool 4 campaign at home to the Scarlets while, in Pool 6, Gloucester host Perpignan and Munster travel to Edinburgh. Tournament organisers European Rugby Cup last week named Cardiff’s Millennium Stadium as the venue for the final, which will take place on Saturday, May 24. But the long-term future of the competition is in doubt. The English and French clubs have served notice they will pull out of the Heineken Cup and the Amlin Challenge Cup when the existing participation agreement ends in May 2014; unless changes are made to the sporting and commercial elements of the two tournaments. center_img Press Associationlast_img read more

Republic open to Given return

first_img Press Association Roy Keane will be at Middlesbrough on Saturday as Ireland run the rule over veteran goalkeeper Shay Given. However, O’Neill has indicated he is open to discussions with the 37-year-old, who has hinted he might like to return, as he plots the way forward after taking over from Giovanni Trapattoni. Millwall’s David Forde is currently the man in possession having replaced Sunderland’s Keiren Westwood, who took over the number one spot after Given’s retirement. Westwood is facing months on the sidelines after undergoing shoulder surgery, leaving Darren Randolph and Rob Elliot as Forde’s understudies when the squad last met up in November last year. center_img Keane, who is manager Martin O’Neill’s assistant, will watch the Teessiders in their Sky Bet Championship clash with Charlton at the Riverside Stadium. Given, whose loan spell at Boro from parent club Aston Villa is due to expire at the end of next month, retired from international football after the Euro 2012 finals with 125 senior caps to his name. last_img read more

Mullins strikes with Sous

first_imgPique Sous gave Willie Mullins his second victory in the last three renewals of the Queen Alexandra Stakes at Royal Ascot with a smart display under Ryan Moore. Press Association Ireland’s champion National Hunt trainer saddled Simenon to win the two-and-three-quarter-mile contest two years ago and Pique Sous, who nearly lost his life last October due to colic, was a heavily backed 11-4 chance to repeat the trick. They versatile grey was a little keen early on and Moore dropped him out towards the rear of the field, but he began to make headway heading down the back straight and was hot on the heels of the leaders rounding the home bend, where he appeared to be travelling much the best. He quashed stamina doubts as he posted a determined length-and-a-half victory. center_img Another Irish challenger, the Aidan O’Brien-trained El Salvador, made considerable headway late in the day to finish second, with Brass Ring another neck away in third. The victory confirmed Moore’s place as leading jockey for the week with his sixth winner of the meeting and his third on the card. Moore said: “It was a very messy race, they only went steady. He travelled beautifully into the race and picked up well. It was a long way, the last furlong, but I got the gaps when they came. When you ride for Willie, it makes it a bit easier.” Mullins added: “Having a Royal Ascot winner is always fantastic. When Ryan hit the front I didn’t think anyone could catch him. “It’s great for the Supreme Horse Racing Club (owners). I picked this horse out for them as he had a lovely pedigree. It’s a been a dream for the racing club to be here and enjoying this. “He’s in the Northumberland Plate, so we’ll see how he comes out of that. I’m not sure what penalty he gets for winning this, but we will have a look at that. I’d like to dedicate the victory to one of my members of staff who had a brain haemorrhage and who is quite ill in hospital.” Tiger Cliff, who was sent off the 5-2 favourite, collapsed and died of a suspected heart attack. last_img read more

ICC World Cup Joe Root makes BIG statement ahead of semi-final clash against Australia

first_imgEngland will play semi-final encounter after 27 years. Joe Root has been most successful batsman for England. Jonny Bairstow scored two consecutive hundred in 2019 World Cup.  Birmingham: England’s star batsman Joe Root says they have the ability to exact revenge for the league stage loss to Australia when the arch-rivals meet in Thursday’s World Cup semifinal. England were downed in convincing fashion by their fiercest rivals at Lord’s last month and looked in serious danger of missing out on the semi-finals at their home tournament.But back-to-back wins over India and New Zealand turned the tables and have put the No.1 ODI side in world on a collision course with Australia at Edgbaston in the second semi-final.England have lost their last two clashes with Australia including a warm-up game before the showpiece Cup began, but before that Root and co had the edge with a series win Down Under and a 5-0 whitewash on home soil.”If you look at the past 11 games against them we have won nine,” he said.”These guys and this group over the last four years, their experience against Australia have been very positive and they have got a lot of success in the bank.”I don’t see that as a big worry for this group, we will be drawing on that confidence that over a long period of time now we have been successful against Australia and we should take that into Thursday.”Add to that the fact that England have found their best form with Jason Roy back firing fit at the top of the order and the mood is clearly buoyant.Root added: “I feel we are in a good place coming into it, I feel like the last two days have almost been like knockout cricket for us.”We have been playing in a high-pressure environment for a while now and hopefully that will hold us in good stead going into this game.”It doesn’t matter (who are the favourites). It comes down to who plays their best cricket on the day. If we play in the manner we have the last two games, we will be a very difficult side to play against.”You can look at form, statistically who is stronger, but it all comes down to who handles the day better, who plays the stronger cricket for the longest period and who will stand up and be victorious at the end of it.”The left-arm attack of Mitchell Starc and Jason Behrendorff, who took a five-for at Lord’s, have proved England’s undoing in the last two encounters.But Root is confident lessons have been learned ahead of that encounter.”They bowled extremely well with the new ball, and those early wickets basically dictated the way the game went,? he added.”It is about understanding that will be the main threat early on, that ball swinging and if we can combat that and make a good start then we give ourselves a better chance.”It is something that seems to have been very effective throughout the tournament, that left-arm angle and throughout one day cricket for a while now and they have exploited that nicely.”But we have also seen that we can score quite nicely if they don’t get it right. Trying to be very objective about it, and clear on how you approach it will be very important.”The guys have faced a lot of left arm stuff over their careers and in build up to last game. There will be a lot talked about it and with that comes pressure for them as well to deliver. It works both ways.”  highlightscenter_img For all the Latest Sports News News, ICC World Cup News, Download News Nation Android and iOS Mobile Apps.last_img read more

FIFA Formally Welcomes Super Falcons to France 2019

first_imgFalcons The sessions were conducted after the Super Falcons’ first training session in Reims which lasted 90 minutes.The 8th FIFA Women’s World Cup finals will kick off on Friday with a clash between France and Korea Republic at the Parc des Princes in Paris. Matches will also take place in Grenoble, Le Havre, Lyon, Montpellier, Nice, Reims, Rennes and Valenciennes.Nigeria file out on Saturday evening against Norway at the Stade Auguste Delaune in Reims, and will tackle Korea Republic at the Stade des Alpes in Grenoble on 12th June, before taking on France at the Roazhon Park in Rennes on 17th June.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram World football-ruling body, FIFA Wednesday formally welcomed African champions Nigeria to the 8th FIFA Women’s World Cup finals.In a session at their Hotel Mercure Reims Centre Cathedral, players and officially performed the ‘Welcome’ ritual and were taken through the rules of the game by FIFA official Sandra Hunt.A second session, on anti-doping, was guided by Dr. Rheema Alhosani.last_img read more

Martin’s 31 points nearly steal victory for Eagles

first_imgFor the second time in as many games, Wisconsin’s opponent shot the lights of the Kohl Center out. Monday, it was Winthrop’s Torrell Martin who was on fire.”Everything he put up went in,” UW senior forward Alando Tucker said. “It was like throwing a rock in the ocean, they were falling.”Martin scored a game-high 31 points on 11-of-18 shooting, 7-of-11 from three-point range.With Eagle guards Michael Jenkins chipping in five three-pointers and Kyle Moore hitting three more from beyond the arc, Winthrop set a Kohl Center record with 15 three-pointers made. It was also the most three-pointers Wisconsin has ever given up to an opponent.But it was Martin’s shooting that kept the Eagles in the game.Whether he was coming off screens, pulling up or just finding himself open, Martin was shooting the ball whenever he got his hands on it, and shooting it well.And while Martin was hitting them, his shots weren’t the easiest to make.”He had to work for those,” UW head coach Bo Ryan said. “He hit some tough ones.”Maybe the toughest shot Martin took came at the end of regulation.After Wisconsin guard Michael Flowers put back an Alando Tucker miss with 10.6 seconds remaining, Winthrop’s last play went to none other than Martin. The Badgers guarded him tightly as the best shot Martin could get off was a falling-away three-pointer at the buzzer.Nevertheless, some of Wisconsin’s players feared the shot would go in, given the way Martin was shooting the ball all game.”My heart sank,” Flowers said of Martin’s shot. “I literally thought I was about to have a seizure on the court. I thought it was going in.”While Winthrop’s three-point shooting certainly kept it in the game, it may have turned out to be its Achilles’ heel in the end.”Shots fall and [Winthrop] lived and died by the three-pointer,” Flowers said. “And they died on that (last) shot.”Flowers blossomsWhereas Martin had a big night for Winthrop, so did the man who was guarding him on Wisconsin’s side of the court.Flowers scored a career-high 21 points, tying Tucker the team-high Monday. Flowers also dished out a team-best five assists.”Unbelievable,” Tucker said of Flowers’ performance. “I was waiting for this to come out, and this was the night for him.”Wisconsin’s starting point guard Kammron Taylor may have had an off-night — scoring six points on 2-of-8 shooting, but his back-court sidekick picked up the slack for him.”We needed everything he gave us on defense, offense, making big shots, making key plays,” Tucker said. “That’s what he’s capable of doing, but this was his come-out night.”But where Flowers made his mark Monday night was at the free throw line. Not only did the junior guard get to the line more than any other Badger, he was efficient from the stripe, shooting 7-of-8.”They shot a lot of free throws,” Winthrop head coach Gregg Marshall said. “And [Flowers] knocked his down.”And just as Martin hit some tough shots for the Eagles, Flowers hit his fair share for the Badgers.Flowers’ first field goal came just under five minutes into the game when he drove the baseline, but then found himself behind the hoop when he went up for the shot.No problem, Flowers thought, and he shot the ball over the glass and in for a bucket.”I practice that shot when I play horse,” Flowers joked after the game.Yet, Flowers was quite nervous right after he took the shot, but not necessarily because he felt as though he would miss it.”As soon as the ball left my hand, I was like, ‘Coach is going to sub me,'” Flowers said. “I did not think the ball was going to go in, but when it went through the net, I was just so happy.”Home-court advantageFor the first time all year, Wisconsin experienced a close game at home. Thus, it was also probably the loudest the Kohl Center crowd has been so far in the young season.With the game coming down to the wire, the Badgers certainly needed the extra boost to pull out the victory.”People around here know basketball, and they knew that we needed a little help [Tuesday],” UW junior forward/center Brian Butch said. “And they gave it to us.”N.D. State strikes againLast year, Wisconsin was upset by a widely unknown team in North Dakota State. The loss came as such a shock to many of the Badger players that it is still used as an example as what not to do in these non-conference games against smaller schools.However, North Dakota State isn’t so unknown any more. This past weekend, the Bison defeated then-No. 9 Marquette.The reason for North Dakota’s recent upsets may lie in a former UW assistant coach who is now a Bison assistant.”They have a thing against Wisconsin teams,” Tucker said of North Dakota State. “Saul Phillips, he’s not playing over there. He knows all the ins and outs of Wisconsin teams.”last_img read more

Mason: UW football never fails to fall short of what rankings say

first_imgI told myself I wasn’t going to write about Saturday’s game, but there were just too many things about the Badgers’ loss to Michigan that have stuck with me.As I sat tucked in the corner of the Big House with the rest of the marching band (I play trumpet, if you’re wondering), the only thing I felt at that time was disbelief. Not anger. Not frustration. Just a feeling of disbelief and confusion as I watched the Badgers’ collapse in the second half to surrender a 19-point halftime lead.As the waning seconds ticked off the clock with the Wolverines’ 27-25 upset victory finally becoming a reality, the crowd of 109,833 began a chant that is still ringing in my ears: “OVERRATED!”Of course, any time a team beats a higher-ranked foe, their fans often resort to this cry. After all, in this case, the Badgers were the ones with the No. 9 ranking, while the Wolverines looked like a team in the rebuilding process. New coach, new quarterback, new running back — nobody expected anything good to come out of Ann Arbor this year.But when the maize-clad maniacs continued their chant, I just thought, “It’s true. They are.”Who’s to argue that Bret Bielema’s bunch was deserving of the top 10 ranking it carried into Saturday’s contest? Look at the two teams ahead of and behind UW in last week’s AP poll: Texas and Alabama at No. 7 and 8, respectively, and Texas Tech and BYU trailing behind at 10 and 11.If any of those four were to come into Camp Randall, I’m not so certain the Badgers would be the favorites. And if Wisconsin hit the road to take on one of those schools on their turf? Forget about it.It seems as though the Badgers play better when they’re not expected to win, almost as if the pressure of being the favorite is too much for them.Take last year, for example. UW traveled to Columbus in early November, where it had the task of facing the No. 1 team in the country — the Ohio State Buckeyes. Although the Badgers were ranked No. 21, it was clear they didn’t stand a snowball’s chance.So what did they do? They took a 10-3 halftime lead in one of the most intimidating atmospheres in college football against the supposed top team in the nation.For three quarters, Wisconsin looked like the better team that day. But a 21-0 fourth quarter in favor of OSU turned UW’s fortunes around, sending the team back to Madison with their third loss of the season.Two years ago, similar story. Same location and timing as three days ago when Wisconsin and Michigan clashed in the Big House in the Big Ten opener. UW came in unranked, while UM, at 3-0, held the No. 6 spot in the polls.Nobody expected the Badgers to come away with a win, let alone put up a fight against the high-powered Wolverines, led at that time offensively by Chad Henne, Mario Manningham and Mike Hart. But UW took a 7-0 lead after the first quarter and went into the locker room at halftime satisfied with a 10-10 tie.While the wheels eventually fell off in the second half, unranked Wisconsin put up more of a fight than anyone gave them a chance to.Unfortunately for the Badgers, Saturday afternoon the tables were turned.At 3-0 and coming off a statement win against Fresno State two weeks prior, Wisconsin was clearly the top team — though the odds makers only had them as 6 1/2 point favorites. Michigan already suffered losses to Utah — at home, no less — and Notre Dame, with its only win coming against Miami of Ohio in Ann Arbor.But as they’ve done many times before, UW showed the rankings don’t matter — or rather that they continue to be placed higher in the polls than they probably belong.Fans have to look no further than last season for another example, when Wisconsin was ranked even higher (No. 5) in its game against unranked Illinois in week six. Instead of coming out and looking like the powerhouse the polls portrayed them as, they instead went into Champaign and came out flat, trailing 17-6 at the half before falling 31-26. That loss dropped them to 19th in the polls — a place that seemed much more comfortable for the Badgers — while the Illini jumped them to take the 18th spot.Ask anyone on the team if they pay attention to the rankings, and they’ll tell you they don’t, saying any team can beat anyone else on any given day.Saturday was proof.Looking back at other comments I heard before this weekend’s game, I can only laugh when I remember what Wolverines fans said to us.“Take it easy on us tomorrow.”“Don’t go too hard on us.”Unfortunately, I think the players must have overheard these remarks and actually took them to heart.Tyler is a senior majoring in journalism. Think the Badgers don’t even deserve to be ranked after Saturday’s game? Let him know about it at read more

Punchestown feature is Champion Hurdle

first_imgThe action’s getting underway at 3.40 with The Champion Hurdle off at 5.30 The grade one Champion Hurdle is the feature on the penultimate day of the Punchestown Festival.Willie Mullins will hope to narrow the gap to Gordon Elliot in the Champion National Hunt Trainer Title – he trains two of the favourites Vroum Vroum Mag and Arctic Fire.Elliots leads by €126,830. Photo: © Punchestownlast_img